Clinical Research & Trials

Study designs and methodologies for clinical and medical research.

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380,585Articles

Articles published on Clinical Research & Trials

380,585 results

10 Jan 2026|10.1016/j.kint.2025.04.023

A randomized controlled trial of intravenous immunoglobulin vs standard of care for the treatment of chronic active antibody-mediated rejection in kidney transplant recipients.

Mulley; William R; Tharmaraj; Dhakshayini; Polkinghorne + 14 more2025·Kidney internationalTier 2

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19 Jan 2026|10.1038/s41598-025-03529-z

Effect of PLISSIT model counseling on the sexual quality of life of infertile women: a randomized controlled trial.

Amini; Reyhane; Taebi; Mahboube; Tehrani + 1 more2025·Scientific reportsTier 2

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11 Jan 2026|10.1371/journal.pone.0321952

Behavioral and emotional difficulties in maltreated children: Associations with epigenetic clock changes and visual attention to social cues.

Ochiai; Keiko; Nishitani; Shota; Yao + 6 more2025·PloS oneTier 2

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25 Jan 2026|10.1186/s12889-025-22284-4

Missed opportunities for detection of hypertension in public health facilities of 18 districts in India, 2022.

Kaviprawin; Mogan; Ramalingam; Archana; Varghese + 32 more2025·BMC public healthTier 1

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27 Jan 2026|10.1038/s43018-025-00916-3

Regorafenib plus avelumab in advanced gastroenteropancreatic neuroendocrine neoplasms: a phase 2 trial and correlative analysis.

Cousin; Sophie; Guégan; Jean-Philippe; Palmieri + 15 more2025·Nature cancerTier 2

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16 Jan 2026|10.1186/s12978-025-02111-0

The burden of infertility in north-eastern Democratic Republic of Congo, a high-fertility region: a cross-sectional study.

Maindo Alongo; Mike-Antoine; Otuli; Noël Labama; Sihakiyolo + 6 more2025·Reproductive healthTier 1

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18 Feb 2026|10.1038/s41598-025-34326-3

External multicenter validation of the eSAH score for predicting outcomes after subarachnoid hemorrhage.

de Oliveira Souza; Natália Vasconcellos; Sharma; Rohan; de Toledo + 11 more2025·Scientific reportsTier 2

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27 Dec 2025|arxiv:2512.18785

Consistent Bayesian meta-analysis on subgroup specific effects and interactions

Renato Panaro; Christian Röver; Tim Friede2025·arXiv Preprint

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6 Jan 2026|10.15407/exp-oncology.2025.03.361

RADIOFREQUENCY ABLATION AS PART OF INTRAHEPATIC TREATMENT STRATEGIES.

Medicine

Valikhnovska; K; Lukashenko; A2025·Experimental oncologyTier 2

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31 Jan 2026|10.1080/22221751.2024.2437242

Predictive metabolite signatures for risk of progression to active TB from QuantiFERON supernatants of household contacts of TB patients.

Daniel; Evangeline Ann; Upadhyay; Shubham; Selvachithiram + 13 more2025·Emerging microbes & infectionsTier 1

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9 Mar 2026|10.1001/jamanetworkopen.2025.13177

Model for Musculoskeletal Injury Risk Factors Among US Army Basic Combat Trainees.

Foulis; Stephen A; Proctor; Susan P; Spiering + 24 more2025·JAMA network openTier 2

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19 Jan 2026|10.1371/journal.pone.0317663

Association between chiropractic spinal manipulation for sciatica and opioid-related adverse events: A retrospective cohort study.

Trager; Robert J; Cupler; Zachary A; Srinivasan + 3 more2025·PloS oneTier 2

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20 Jan 2026|10.1001/jamacardio.2025.1399

Association of Endothelial Dysfunction With Chronic Marijuana Smoking and THC-Edible Use.

Mohammadi; Leila; Navabzadeh; Mina; Jiménez-Téllez + 19 more2025·JAMA cardiologyTier 2

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23 Jan 2026|10.1038/s41598-025-12092-6

Access to translated invitations online increases involvement of linguistically diverse households in a population-based study: a cluster randomized controlled study.

Herrera-Espejel; Paula S; Mildner; Thomas; Pohlabeln + 4 more2025·Scientific reportsTier 2

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10 Jan 2026|10.1136/bmjopen-2025-101643

International comparison of medicines approvals in the UK: a retrospective analysis.

Ogunyemi; Ayomikun Oluwaseun; Uteh; Cyril Onwuelazu; Fairbairn + 3 more2025·BMJ openTier 2

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13 Jan 2026|10.1016/j.ijnurstu.2025.105072

The impacts of a mHealth platform-enabled lifestyle-integrated multicomponent exercise program on reversing pre-frailty in community-dwelling older adults: A randomized controlled trial.

Li; Na; Wang; Nan; Xu + 5 more2025·International journal of nursing studiesTier 1

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7 Mar 2026|10.1016/j.jacc.2024.11.025

Clinical Effect of Genetic Testing in Inherited Cardiovascular Diseases: A 14-Year Retrospective Study.

Grondin; Steffany; Neveu; Benjamin; Soltani + 27 more2025·Journal of the American College of CardiologyTier 2

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30 Jan 2026|arxiv:2501.18383

A tutorial on conducting sample size and power calculations for detecting treatment effect heterogeneity in cluster randomized trials with linear mixed models

Mary Ryan Baumann; Monica Taljaard; Patrick J. Heagerty; Michael O. Harhay; Guangyu Tong; Rui Wang; Fan Li2025·arXiv Preprint

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9 Jan 2026|10.1371/journal.pone.0328786

The Healthy Homes Study: Protocol for a cluster randomized trial of a place-based smoke-free home intervention in affordable housing.

Hawes; Mark R; Chakravarty; Deepalika; Cheng + 6 more2025·PloS oneTier 2

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17 Jan 2026|10.1186/s12889-025-21280-y

Prevalence and associated factors of multidimensional poverty among rural households in East Gojjam zone, Northern Ethiopia: a community-based cross-sectional study.

Ayele; Amare Wubishet; Ewinetu; Yeshiwas; Delesho + 3 more2025·BMC public healthTier 1

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