Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease

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Among key Western lifestyle factors, a diet poor in fiber is associated with prevalence of high BP. Francine C. Marques shows that a lack of prebiotic dietary fiber leads to the development of a hypertensinogenic gut microbiota, hypertension and its complications, and demonstrate a role for G-protein coupled-receptors (GPCRs) that sense gut metabolites.

Institution: Monash University

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Among key Western lifestyle factors, a diet poor in fiber is associated with prevalence of high BP. Francine C. Marques shows that a lack of prebiotic dietary fiber leads to the development of a hypertensinogenic gut microbiota, hypertension and its complications, and demonstrate a role for G-protein coupled-receptors (GPCRs) that sense gut metabolites.

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Image courtesy of interviewee. May 1, 2023

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