Targeted mutation of secretogranin-2 disrupts sexual behavior and reproduction in zebrafish

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The secretory granule protein secretogranin-2 is processed to the bioactive neuropeptide secretoneurin. While these are expressed in hypothalamic neurons and anterior pituitary cells, a role in hormonal control of reproduction is unknown. Vance L. Trudeau discusses in vivo evidence that secretogranin-2 plays critical roles in fertility regulation. Image courtesy of Vance L. Trudeau.

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