Blood Biomarkers in the Diagnosis of Alzheimer’s Disease

Oligomeric forms of the peptide, β-amyloid, (Aβ) are known to be toxic to human and rodent neurones, and have been identified as possible causative agents in the loss of cognitive function in Alzheimer’s Disease (AD). An ELISA assay has been developed capable of detecting oligomeric forms of Aβ in biological fluids, but not detecting monomeric species. The ELISA has been validated with a number of synthetic variant sequences of Aβ and the effects of known inhibitors of Aβ oligomer formation. Significantly raised levels of oligomers were detected in sera samples from AD patients, compared to age-matched control sera.

Publication

Image courtesy of interviewee

Leave a Reply

Your email address will not be published.

×
Guest visitors to the Faculti website can view any insight monthly. You have insight(s) remaining for this month

Register for free as an individual and view thousands of insights in our archive today or subscribe for subject access.

You may already have institutional access to Faculti. Please access Faculti using your institution credentials.

Copyright © Faculti Media Limited 2022. All rights reserved.
error:

Add the Faculti Web App to your Mobile or Desktop homescreen

Install
×