Mechanisms of calcium transient and action potential alternans in cardiac cells and tissues


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Alternation of cardiac action potential duration (APD) from beat to beat and concurrent alternation of the amplitude of the calcium transient are regarded as important arrhythmia mechanisms. These phenomena are causally interrelated and can be reliably evoked by an increase in beat frequency or by ischemia.

Image courtesy of interviewee. December 20, 2017

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