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Potential Benefits of Psilocybin for Lupus Pain

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Daniel Arkfeld suggests that psilocybin could provide long-lasting pain relief for Lupus patients. Further studies on this topic are warranted.

Image courtesy of interviewee. December 5, 2023

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This video video discusses a case study involving the use of psilocybin (found in "magic mushrooms") in treating pain associated with lupus, an autoimmune disorder where the body attacks itself instead of fighting infections. The speaker notes that lupus can be life-threatening and cause significant pain and fatigue.

They explain that while psilocybin research has primarily focused on microdosing for psychiatric benefits, a patient who took a macro dose of six grams—far above the typical microdosing range—experienced relief from chronic pain, despite having a negative trip. This video video case is presented as a significant finding, as it is the first documented instance of psilocybin potentially benefiting lupus-related pain.

Key observations include the importance of dosage, with higher doses potentially needed for pain relief, and the necessity of careful monitoring due to risks of adverse psychological effects. The speaker advocates for more research into psilocybin's therapeutic potential, especially for chronic pain management, while also advising against self-treatment and highlighting the legal status of psilocybin in various states.

Overall, the case demonstrates a promising, albeit preliminary, link between psilocybin and pain relief in autoimmune conditions, suggesting a need for further studies to explore this relationship.

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Here are some articles that are similar in theme and content to the video about psilocybin and its potential therapeutic uses, particularly in relation to autoimmune disorders like lupus:

1. **"Psilocybin and Chronic Pain: New Perspectives"**
This article explores the recent research on psilocybin and its potential effects on chronic pain management. It reviews various studies that investigate dosages and outcomes, focusing on how psychedelics might alter pain perception and provide relief.

2. **"The Role of Psychedelics in Treating Autoimmune Disorders"**
This article discusses how psychedelics, including psilocybin, are being examined for their influence on autoimmune diseases such as lupus and rheumatoid arthritis. It highlights case studies and emerging research that suggest a connection between psychedelics and immune response modulation.

3. **"Psychedelics as Therapeutics: Understanding the Science"**
This comprehensive review examines the scientific background of psilocybin and other psychedelics in treating mental health disorders and chronic pain. It addresses the challenges of dosing, potential benefits, and risks associated with psychedelic use in therapeutic settings.

4. **"Understanding Lupus: New Treatments on the Horizon"**
Focusing specifically on lupus, this article discusses various treatment options, including innovative therapies that investigate the use of psychedelics. It provides insights into autoimmune mechanisms and the complexity of managing chronic pain associated with lupus.

5. **"Microdosing vs. Macrodosing: What Works Best for Pain Relief?"**
In this article, the differences between microdosing and macrodosing psychedelics are explored, specifically in the convideo of pain relief. It analyzes patient experiences, research findings, and suggests directions for future studies.

6. **"Clinical Trials of Psilocybin: Implications for Pain Management"**
This piece reviews ongoing clinical trials that involve psilocybin and their implications for pain management, including chronic conditions such as fibromyalgia and lupus. It emphasizes the need for rigorous research to understand proper dosing and therapeutic outcomes.

7. **"Legal Status of Psilocybin: Impacts on Research and Treatment"**
This article discusses the legal landscape surrounding psilocybin in different regions, its implications for research, and the challenges faced by patients and advocates in accessing psychedelic therapy for conditions like lupus.

These articles collectively provide a broader convideo on the use of psilocybin and other psychedelics in medical research, especially relating to chronic pain and autoimmune disorders.

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Yeah, so lupus is a common disorder

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that we treat in rheumatology.

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Uh, essentially it's where the body, instead

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of fighting off an infection for, unclear reasons,

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turns on itself and tends to attack itself.

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Uh, it can be very much, life-threatening, affecting,

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major organ involvement.

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It can also cause a significant amount of pain

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and fatigue, as in, this case

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that we'll be, talking about today.

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Well, the neuro, pathways

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that Psilocybins may be developing is a very,

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key area of, interest in pain management issue

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as well as in psychiatry.

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Uh, what's unique about our, case and presentation

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and paper that we publish is that it involves lupus,

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which has not been, described, before,

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and this is going back probably in evolution

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of neural pathways.

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Psilocybin seem to be very important, in from evolution,

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to, current pathways

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and trying to use them to help, for a variety

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of different syndromes.

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Well, this is interesting that this was a, a case report,

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from a patient who came in

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and he described what happened to him.

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Uh, he assumed I probably would have no interest in it,

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not one of, presented since, you know,

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psilocybins quote,

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magic mushrooms are illegal in California.

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Uh, he had, received the, the mushroom therapy

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in Oregon, where it is legal.

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Uh, but I found it very fascinating, aware

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of different issues from the pain world.

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Uh, there was one case of a gentleman in a few years ago

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who had an amputation of his leg,

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which caused chronic phantom limb pain.

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Nothing was working, who was essentially the pain resolved

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after he took psilocybin, macro dosing therapy.

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So it, this is kind of like the second case of something,

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but that, that reported that, could find,

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and I thought very fascinating.

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So we decided to write it up and research it,

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and that's what this article is all about.

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It works on serotonin receptors.

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Serotonin is very much involved in pain.

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It works actually in the frontal cortex,

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and, you know, from depression

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and a variety of different, psychiatric syndrome

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that's been used quite a bit.

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Mostly microdosing though,

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this gentleman actually macro dosed,

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which I think is unique

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and probably led to, more prolonged,

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remission from his pain.

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Uh, well, this study is the very first report in lupus

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and really an autoimmune conditions, of possible benefit

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of psilocybins in pain.

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The pain that occurs in these, syndromes,

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it obviously needs to be reproduced, needs

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to be more formally studied to really determine what,

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benefits could, could happen,

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but it's actually very exciting, in information.

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So I think the key takeaways are several.

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One is, you know, the dosing of psilocybins is

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Extremely important.

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Mostly people are microdosing for psychiatric benefits,

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but for pain pathways, it seems like you need

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possibly a much larger amount when you microdose.

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Maybe it lasts for hours of the benefit,

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but by macro dosing, which typically is between two

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to five grams, an episode,

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which causes significant amount of risk as far as,

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psychotic, events or, you know, bad trips

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or whatever you wanna call it.

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Um, this gentleman actually took six grams,

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which is a extremely high amount.

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And, and this was not my recommendation.

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He did this on his own, and he had a bad trip.

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He didn't, he went there to try to find himself

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and, thought mentally it would, help him in life,

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at 67, and it, that didn't occur.

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So there's no benefit, from that aspects for him.

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And actually he, it was kind of a negative experience,

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which we find on these high dose, therapies,

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but the fact that his pain result was not,

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we weren't looking for that, but it was, fascinating

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that it did, resolve it.

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So certainly the dosing between micro to macro dosing,

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is very important in the takeaway,

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and that's what probably needs to be studied quite a bit.

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Uh, secondly though is, you know, the risk of side effects,

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especially if you have depression or anxiety

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or something, the brain with his serotonin,

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effects could be beneficial, but it also could be negative.

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And so that's something that needs to be monitored as well.

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And he actually had a sharmin type person that monitored him

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through this whole event, which is very helpful

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and really necessary if you were to do this.

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Uh, the other thing is

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that these are currently illegal in our, in California,

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in most states, in the united, in the us a lot

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of research is going on,

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currently legal in Colorado and in Oregon.

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Um, and our experience is very limited because of that.

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But I do think there is definitely future need

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for research into this,

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and hopefully provide benefit for chronic pain sufferers

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for a variety of different, syndromes.

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Cytokines, which are, substances that,

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transmit, into the spinal fluid that seem

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to control pain are very important in rheumatology.

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Uh, interleukin six,

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inter other interleukins that we follow.

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And they seem to actually be increased in, in spinal fluid

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in many different pain, chronic pain syndromes.

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And so, you know, the targeting that instead of taking

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a pain pill, an anti-inflammatory

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and opiate, possibly cytokine therapies, possibly

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psilocybin therapies, all will be developed in the future

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and hopefully, provide relief for really chronic

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pain suffers, and especially people

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that are severely affected, with pain management.

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But if this is just a very preliminary observation,

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there are risks, just don't go do this on your own.

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Talk to your, doctor,

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you know, participate in a study.

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I think Johns Hopkins is doing many studies on psilocybins

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and pain, and I just said it's really new novel,

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and, I think it's looking forward.

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The other thing is compared to like, ayahuasca or LSD

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or these other things, just mushrooms are much less potent

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than them,

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and don't tend to have nearly the risk of side effects

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of other, hallucinogens.

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But it is something that obviously macro dosing,

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not taking like, you know, 0.1 milligram

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or 10 milligrams even,

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but this guy took actually six grams,

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which is a tremendous amount, for him.

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Um, but he had this benefit of pain relief.

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Uh, so you assume that he formed a neural pathway that kind

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of bypasses old pain pathways,

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and why it's relief, which is, I mean, awesome

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and intriguing and hopefully reproducible

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and maybe it will,

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many studies I'm sure will come in the future for this.

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