Simvastatin causes pulmonary artery relaxation by blocking smooth muscle ROCK and calcium channels

Simvastatin reduces pulmonary arterial pressure and right ventricular hypertrophy in animal models of pulmonary arterial hypertension (PAH) and is thought to restore endothelial dysfunction. In vivo effects of drugs are complicated by several factors and little is known of the direct effects of statins on pulmonary arteries. Mais Absi discusses the direct effects of simvastatin on pulmonary arteries isolated from rats with or without monocrotaline-induced PAH. 

Read the Study

Image courtesy of interviewee. May 22, 2023

Log-in or Sign-up to Faculti
Currently viewing this subject insight as a guest. You have insight(s) remaining for this month.

Leave a Reply

Your email address will not be published. Required fields are marked *

Copyright © Faculti Media Limited 2013 - 2024. All rights reserved.