Dynamics of ACTH and Cortisol Secretion and Implications for Disease

The past decade has seen several critical advances in our understanding of hypothalamic–pituitary–adrenal (HPA) axis regulation. Stafford Lightman discusses recent studies that have shown that circadian rhythmicity of the major output of this system comprises varying amplitude pulses that exist due to a subhypothalamic pulse generator.

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Image courtesy of interviewee. February 21, 2023

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